The Phosphatase Activity in Spondylitis Ankylopoietica

The phosphatase activity in spondylitis ankylopoietica.

Introduction Ankylosing spondylitis is at present a disease of unknown aetiology and many theories have been put forward as to its origin. Buckley (1945) reviewed a-mass of evidence bearing on a possible biochemical mechanism which involves serum phosphatase as a cardinal factor in producing the abnormal ligamentous calcification and the bony changes which constitute the main pathological featu...

Streptococcal Antifibrinolysin in Rheumatoid Arthritis and Spondylitis Ankylopoietica.

Increased serum alkaline phosphatase activity in ankylosing spondylitis.

Raised serum alkaline phosphatase (AP) levels were found in 13 of 76 patients (17%) with ankylosing spondylitis (AS), and 11 of these 13 underwent further investigation to determine the origin of the increased enzyme activity. Three had levels within the normal reference range on re-estimation, and, of the remaining 8, AP isoenzyme studies indicated an increased liver fraction in 6. Serum gamma...

Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)

Background: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-s...

The effects of chromium and cadmium on the activity of alkaline phosphatase lsoenzmes in rats

The aim of this study was to Investigate the toxic effects of chromium and cadmium on the activity of two isoenzymes of alkaline phosphatase in vitro and in vivo experiments. Oral administration and peritoneal injection of  CdCl2 or CrCl3 in rats reduced serum alkaline phosphatase by 21.5℅ and 25.5℅ respectively. At the same time high molecular weight alkaline phosphatase was elevated by 138℅ a...